Presenter(s): Larry C. Driver, MD, and Jeffrey Fudin, PharmD, DAIPM, FCCP, FASHP
About the webinar: Considering drug-drug interactions is key to selecting the safest and most efficacious combinations of analgesic drug classes and adjuvants (e.g., antidepressants, anticonvulsants). In order to appropriately identify drug-drug interactions, it is essential that clinicians understand the relevant common mechanisms for these, in particular those mediated by the cytochrome P450 (CYP450) system and P-glycoprotein. Pharmacogenetic differences among patients can also impact efficacy, drug interactions, and ability to tolerate medications. This webinar will describe opioid and non-opioid pharmacokinetics and drug-drug interactions and their impact on patient analgesia. Adverse effects when combining analgesics will be further explored through cases studies.
- Classify cytochrome P450 (CYP450) system nomenclature and describe role of CYP450 and p-glycoprotein in pharmacokinetics.
- Recognize key CYP450 mediated drug-drug interactions.
- Identify potential drug-drug interactions and important considerations when prescribing various analgesic classes and adjuvants.
Continuing Education: The American Academy of Pain Medicine (AAPM) provides an enduring webinar titled “A Shifting Paradigm: From Biomedical to Biopsychosocial Interactions” and offers continuing medical education (CME) for physicians. Successful completion requires that participants register for the webinar and complete a pre-test, participate, and complete an online post-test and evaluation. Participants receive their CME certificates after they submit their evaluations online.
Accreditation: The American Academy of Pain Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.
Credit Designation: The American Academy of Pain Medicine designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.