Opioid Dosing in Renal and Hepatic Impairment

Opioid analgesics are considered the mainstay of pain management. The primary goal of analgesia is optimizing the patient’s comfort. However, opioid dosing may be complicated in patients with renal and/or hepatic impairment. Most recommendations are based on case reports; therefore, appropriate analgesic agent selection requires a thorough understanding of the drugs’ pharmacokinetics and side-effect profiles. Should morphine and hydromorphone be dose-reduced in patients with hepatic or renal insufficiency? Read more at Medscape.*

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