A Detailed Exploration into the Association of Prescribed Opioid Dosage and Overdose Deaths Among Patients with Chronic Pain

From the Journal of the Medical Care Section, American Public Health Association–High opioid dosage has been associated with overdose, and clinical guidelines have cautioned against escalating dosages above 100 morphine-equivalent mg (MEM) based on the potential harm and the absence of evidence of benefit from high dosages. However, this 100 MEM threshold was chosen somewhat arbitrarily.

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