Deaths Higher With Methadone vs Morphine in Chronic Pain

From JAMA Internal Medicine: Out-of-Hospital Mortality Among Patients Receiving Methadone for Noncancer Pain

Growing methadone use in pain management has raised concerns regarding its safety relative to other long-acting opioids. Methadone hydrochloride may increase the risk for lethal respiratory depression related to accidental overdose and life-threatening ventricular arrhythmias.

Read more.