Patients taking opioid medications for chronic pain over the long-term have an increased risk of serious dose-dependent harms, according to a review of the evidence on long-term opioid use by the Agency for Healthcare Research and Quality (AHRQ). In addition, AHRQ found little evidence supporting the benefits of long-term use of opioids for chronic pain. View an abstract of the study.* *You must be a subscriber to the Journal of the American Medical Association (JAMA) to view the full content. If you do not have a JAMA account, please follow the on-screen prompts.